• Non-linear optical microscopy as a novel quantitative and label-free imaging modality to improve the assessment of tissue-engineered cartilage 

      Martinez, Inigo Zubiavrre; Islam, Ashraful; Elisabeth, Romijn; Lilledahl, Magnus Borstad (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10)
      Objective: <br>Current systems to evaluate outcomes from tissue-engineered cartilage (TEC) are sub-optimal. The main purpose of our study was to demonstrate the use of second harmonic generation (SHG) microscopy as a novel quantitative approach to assess collagen deposition in laboratory made cartilage constructs. <br>Methods: <br>Scaffold-free cartilage constructs were obtained by condensation ...
    • Optical investigation of osteoarthritic human cartilage (ICRS grade) by confocal Raman spectroscopy: a pilot study 

      Kumar, Rajesh; Grønhaug, Kirsten Marie; Afseth, Nils Kristian; Isaksen, Vidar; Davies, Catharina de Lange; Drogset, Jon Olav; Lilledahl, Magnus Borstad (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      Biomolecular changes in the cartilage matrix during the early stage of osteoarthritis may be detected by Raman spectroscopy. The objective of this investigation was to determine vibrational spectral differences among different grades (grades I, II, and III) of osteoarthritis in human osteoarthritic cartilage, which was classified according to the International Cartilage Repair Society (ICRS) grading ...